2. Academic Validation
  3. Antineoplastic agents. 570. Isolation and structure elucidation of bacillistatins 1 and 2 from a marine Bacillus silvestris

Antineoplastic agents. 570. Isolation and structure elucidation of bacillistatins 1 and 2 from a marine Bacillus silvestris

  • J Nat Prod. 2009 Mar 27;72(3):366-71. doi: 10.1021/np800603u.
George R Pettit 1,  John C Knight,  Delbert L Herald,  Robin K Pettit,  Fiona Hogan,  Venugopal J R V Mukku,  John S Hamblin,  Michael J Dodson,  Jean-Charles Chapuis
Affiliations

Affiliation

  • 1 Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, P.O. Box 871604, Tempe, Arizona 85287-1604, USA. bpettit@asu.edu
PMID: 19226154 DOI: 10.1021/np800603u
Abstract

Two new cyclodepsipeptides designated bacillistatins 1 (1) and 2 (2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from a Pacific Ocean (southern Chile) crab. Each 12-unit cyclodepsipeptide strongly inhibited growth of a human Cancer cell line panel, with GI(50)'s of 10(-4)-10(-5) microg/mL, and each compound was active against antibiotic-resistant Streptococcus pneumoniae. The structures were elucidated by a combination of X-ray diffraction and mass and 2D NMR spectroscopic analyses, together with chemical degradation.

Figures