2. Academic Validation
  3. Structure-activity relationship studies of curcumin analogues

Structure-activity relationship studies of curcumin analogues

  • Bioorg Med Chem Lett. 2009 Apr 1;19(7):2065-9. doi: 10.1016/j.bmcl.2009.01.104.
James R Fuchs 1,  Bulbul Pandit,  Deepak Bhasin,  Jonathan P Etter,  Nicholas Regan,  Dalia Abdelhamid,  Chenglong Li,  Jiayuh Lin,  Pui-Kai Li
Affiliations

Affiliation

  • 1 Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 338 Parks Hall, 500 West 12th Avenue, Columbus, OH 43210, USA.
PMID: 19249204 DOI: 10.1016/j.bmcl.2009.01.104
Abstract

Two series of curcumin analogues, a total of twenty-four compounds, were synthesized and evaluated. The most potent compound, compound 23, showed potent growth inhibitory activities on both prostate and breast Cancer lines with IC(50) values in sub-micromolar range, fifty times more potent than curcumin. Curcumin analogues might be potential anti-tumor agents for breast and prostate cancers.

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