2. Academic Validation
  3. Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants

Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants

  • Bioorg Med Chem Lett. 2009 Apr 15;19(8):2299-304. doi: 10.1016/j.bmcl.2009.02.077.
Stefano Pegoraro 1,  Martin Lang,  Tobias Dreker,  Jürgen Kraus,  Svetlana Hamm,  Cathal Meere,  Juliane Feurle,  Stefan Tasler,  Sylvia Prütting,  Zerrin Kuras,  Violeta Visan,  Stephan Grissmer
Affiliations

Affiliation

  • 1 4SC AG, Am Klopferspitz 19a, 82152 Planegg-Martinsried, Germany.
PMID: 19282171 DOI: 10.1016/j.bmcl.2009.02.077
Abstract

New structural classes of K(V)1.3 and IK-1 ion channel blockers have been identified based on a virtual high throughput screening approach using a homology model of KcsA. These compounds display inhibitory effects on T-cell and/or keratinocyte proliferation and immunosuppressant activity within a DTH animal model.

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