2. Academic Validation
  3. Alkenyl substituted bicyclic nucleoside analogues retain nanomolar potency against Varicella Zoster Virus

Alkenyl substituted bicyclic nucleoside analogues retain nanomolar potency against Varicella Zoster Virus

  • Bioorg Med Chem. 2009 Apr 15;17(8):3025-7. doi: 10.1016/j.bmc.2009.03.022.
Christopher McGuigan 1,  Olivier Bidet,  Marco Derudas,  Graciela Andrei,  Robert Snoeck,  Jan Balzarini
Affiliations

Affiliation

  • 1 Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, UK. mcguigan@cardiff.ac.uk
PMID: 19328697 DOI: 10.1016/j.bmc.2009.03.022
Abstract

Novel alkenyl substituted aryl bicyclic furano pyrimidines have been prepared and evaluated in vitro against Varicella Zoster Virus (VZV). The para-substituted analogues retain the nanomolar potency we have reported for p-alkyl analogues, while the ortho- and meta-alkenyl systems lose 3-4 orders of potency.

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