2. Academic Validation
  3. In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin

In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin

  • J Antibiot (Tokyo). 2009 Jun;62(6):303-8. doi: 10.1038/ja.2009.32.
Aki Ishiyama 1,  Kazuhiko Otoguro,  Masato Iwatsuki,  Miyuki Namatame,  Aki Nishihara,  Kenichi Nonaka,  Yuta Kinoshita,  Yoko Takahashi,  Rokuro Masuma,  Kazuro Shiomi,  Haruki Yamada,  Satoshi Omura
Affiliations

Affiliation

  • 1 Research Center for Tropical Diseases, Center for Basic Research, Kitasato Institute for Life Sciences and Graduate School of Infectious Control Sciences, Kitasato University, Tokyo, Japan.
PMID: 19407848 DOI: 10.1038/ja.2009.32
Abstract

In the course of our screening for antitrypanosomal compounds from soil Microorganisms, as well as from the Antibiotics library of the Kitasato Institute for Life Sciences, we found three peptide Antibiotics, leucinostatin (A and B), alamethicin I and tsushimycin, which exhibited potent or moderate antitrypanosomal activity. We report here the in vitro and in vivo antitrypanosomal properties and cytotoxicities of leucinostatin A and B, alamethicin I and tsushimycin compared with suramin. We also discuss their possible mode of action. This is the first report of in vitro and in vivo trypanocidal activity of leucinostatin A and B, alamethicin I and tsushimycin.

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