2. Academic Validation
  3. Antimalarial and cytotoxic depsidones from the fungus Chaetomium brasiliense

Antimalarial and cytotoxic depsidones from the fungus Chaetomium brasiliense

  • J Nat Prod. 2009 Aug;72(8):1487-91. doi: 10.1021/np9003189.
Primmala Khumkomkhet 1,  Somdej Kanokmedhakul,  Kwanjai Kanokmedhakul,  Chariya Hahnvajanawong,  Kasem Soytong
Affiliations

Affiliation

  • 1 Natural Products Research Unit, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
PMID: 19663417 DOI: 10.1021/np9003189
Abstract

Four new depsidones, mollicellins K-N (1-4), and six known depsidones, mollicellins B (5), C (6), E (7), F (8), H (9), and J (10), along with two known sterols were isolated from the fungus Chaetomium brasiliense. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic data and chemical transformation. Among these isolates, 1-3, 5-7, and 10 exhibited antimalarial activity against Plasmodium falciparum. Only 1 exhibited antimycobacterial activity against Mycobacterium tuberculosis and Antifungal activity against Candida albicans using in vitro assays. In addition, 1-10 showed cytotoxicity against the KB, BC1, NCI-H187, and five cholangiocarcinoma cell lines.

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