2. Academic Validation
  3. Bioactive Nortriterpenoids from Schisandra grandiflora

Bioactive Nortriterpenoids from Schisandra grandiflora

  • J Nat Prod. 2009 Sep;72(9):1678-81. doi: 10.1021/np900292e.
Wei-Lie Xiao 1,  Yan-Qing Gong,  Rui-Rui Wang,  Zhi-Ying Weng,  Xiao Luo,  Xiao-Nian Li,  Guang-Yu Yang,  Fei He,  Jian-Xin Pu,  Liu-Meng Yang,  Yong-Tang Zheng,  Yang Lu,  Han-Dong Sun
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.
PMID: 19685905 DOI: 10.1021/np900292e
Abstract

Three new nortriterpenoids, schigrandilactones A-C (1-3), along with eight known compounds, were isolated from an organic solvent extract of Schisandra grandiflora. Compounds 1 and 2 feature a spirocyclic moiety in their structures, and compound 3 was characterized with a new oxygenated pattern. The relative configurations of 1 and 3 were determined through single-crystal X-ray experiments. In addition, compounds 1 and 2 displayed cytotoxic activity against two human Cancer cell lines, and compound 3 showed anti-HIV-1 inhibition in infected C8166 cells.

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