2. Academic Validation
  3. mu-Opioid/5-HT4 dual pharmacologically active agents-efforts towards an effective opioid analgesic with less GI and respiratory side effects (Part I)

mu-Opioid/5-HT4 dual pharmacologically active agents-efforts towards an effective opioid analgesic with less GI and respiratory side effects (Part I)

  • Bioorg Med Chem Lett. 2009 Oct 1;19(19):5679-83. doi: 10.1016/j.bmcl.2009.08.016.
Liming Shao 1,  Fengjiang Wang,  Michael C Hewitt,  Timothy J Barberich
Affiliations

Affiliation

  • 1 Sepracor Inc., 84 Waterford Drive, Marlborough, MA 01752, USA. liming.shao@sepracor.com
PMID: 19700325 DOI: 10.1016/j.bmcl.2009.08.016
Abstract

Novel compounds were prepared that united the pharmacologies of the mu-opioid tramadol with the 5-HT4 agonists metoclopramide and norcisapride. The synthesis, chiral separation and in vitro activity of the new compounds is described.

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