2. Academic Validation
  3. Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2

Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2

  • Bioorg Med Chem Lett. 2009 Oct 15;19(20):5893-7. doi: 10.1016/j.bmcl.2009.08.066.
Mark Andrews 1,  Alan Brown,  Jean-Yves Chiva,  David Fradet,  David Gordon,  Mark Lansdell,  Malcolm MacKenny
Affiliations

Affiliation

  • 1 Discovery Chemistry, Pfizer Global Research and Development, Sandwich, United Kingdom.
PMID: 19740658 DOI: 10.1016/j.bmcl.2009.08.066
Abstract

A second wave of potential SSRIs with high ease of synthetic accessibility were designed based on the reported selective serotonin re-uptake inhibitor litoxetine and our own previous work in this area. Preparation and subsequent optimisation yielded a range of potent and highly selective SSRIs.

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