2. Academic Validation
  3. Biphenyls from Berberis koreana

Biphenyls from Berberis koreana

  • J Nat Prod. 2009 Nov;72(11):2061-4. doi: 10.1021/np900460j.
Ki Hyun Kim 1,  Sang Un Choi,  Sang Keun Ha,  Sun Yeou Kim,  Kang Ro Lee
Affiliations

Affiliation

  • 1 Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea.
PMID: 19813743 DOI: 10.1021/np900460j
Abstract

Three new biphenyls, berbekorin A (1), 2'-hydroxy-3,4,5-trimethoxybiphenyl (2), and 4,5-dihydroxy-3-methoxybiphenyl (3), together with 11 known biphenyls (4-14), were isolated from the n-hexane-soluble fraction of the MeOH extract of the trunk of Berberis koreana. The structures of 1-3 were determined by spectroscopic methods, including 1D and 2D NMR analysis. Compound 1 exhibited cytotoxic activity against the SK-MEL-2 skin melanoma cell line, in particular. Moreover, compounds 2, 5, 6, and 14 inhibited NO production in LPS-activated BV-2 cells, a microglial cell line.

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