2. Academic Validation
  3. 2'-Fluorosugar analogues of the highly potent anti-varicella-zoster virus bicyclic nucleoside analogue (BCNA) Cf 1743

2'-Fluorosugar analogues of the highly potent anti-varicella-zoster virus bicyclic nucleoside analogue (BCNA) Cf 1743

  • Bioorg Med Chem Lett. 2009 Nov 15;19(22):6264-7. doi: 10.1016/j.bmcl.2009.09.116.
Christopher McGuigan 1,  Marco Derudas,  Maurizio Quintiliani,  Graciela Andrei,  Robert Snoeck,  Geoffrey Henson,  Jan Balzarini
Affiliations

Affiliation

  • 1 Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF103XF, UK. mcguigan@cf.ac.uk
PMID: 19833513 DOI: 10.1016/j.bmcl.2009.09.116
Abstract

We report the preparation of 2'-alpha-F, 2'-beta-F and 2',2'-difluoro analogues of the leading anti-varicella zoster virus (VZV) pentylphenyl BCNA Cf 1743. VZV thymidine kinase showed the highest phosphorylating capacity for the beta-fluoro derivative, that retained equal Antiviral potency as the parent compound. In contrast, the alpha-fluoro- and 2',2'-difluoro BCNA derivatives were markedly less (approximately 100-fold) antivirally active.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-107025
    VZVTK Inhibitor