2. Academic Validation
  3. The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144

The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144

  • J Nat Prod. 2009 Nov;72(11):1944-8. doi: 10.1021/np9004882.
Deborah M Roll 1,  Laurel R Barbieri,  Ramunas Bigelis,  Leonard A McDonald,  Daniel A Arias,  Li-Ping Chang,  Maya P Singh,  Scott W Luckman,  Thomas J Berrodin,  Matthew R Yudt
Affiliations

Affiliation

  • 1 Chemical Sciences, Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965, USA. rolld@wyeth.com
PMID: 19863083 DOI: 10.1021/np9004882
Abstract

Four new indolosesquiterpenes, lecanindoles A-D (1-4), were isolated from fermentations of the terrestrial fungus Verticillium lecanii 6144. The structures of compounds 1-4 were elucidated from analysis of spectroscopic data. Compound 2 was reduced to give 4 and its isomer 5. Compound 4 was found to be a potent and selective Progesterone Receptor Agonist with an EC50 of 1.1 +/- 0.4 nM in a cell-based luciferase reporter assay.

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