Lamiridosins, hepatitis C virus entry inhibitors from Lamium album

J Nat Prod. 2009 Dec;72(12):2158-62. doi: 10.1021/np900549e.

Hongjie Zhang ¹, Katharina Rothwangl, Andrew D Mesecar, Ali Sabahi, Lijun Rong, Harry H S Fong

Affiliations

Affiliation

1 Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Illinois 60612, USA. zhanghj@uic.edu

PMID: 19904996 DOI: 10.1021/np900549e

Abstract

Phytochemical study of the aqueous extract of the flowering tops of Lamium album led to identification of the Antiviral iridoid isomers lamiridosins A and B (1, 2). These compounds were found to significantly inhibit hepatitis C virus entry (IC(50) 2.31 muM) in vitro. Studies of 14 iridoid analogues showed that, while the parent iridoid glucosides demonstrated no anti-HCV entry activity, the aglycones of shanzhiside methyl ester (4), loganin (5), loganic acid (6), geniposide (10), verbenalin (12), eurostoside (15), and picroside II (17) exhibited significant anti-HCV entry and anti-infectivity activities.

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