2. Academic Validation
  3. Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid

Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid

  • Eur J Med Chem. 2010 Mar;45(3):1078-86. doi: 10.1016/j.ejmech.2009.12.002.
Ramendra K Singh 1,  Diwakar Rai,  Dipti Yadav,  A Bhargava,  J Balzarini,  E De Clercq
Affiliations

Affiliation

  • 1 Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad 211002, India.
PMID: 20034711 DOI: 10.1016/j.ejmech.2009.12.002
Abstract

Curcumin bioconjugates, viz. di-O-tryptophanylphenylalanine curcumin (2), di-O-decanoyl curcumin (3), di-O-pamitoyl curcumin (4), di-O-bis-(gamma,gamma)folyl curcumin (6), C(4)-ethyl-O-gamma-folyl curcumin (8) and 4-O-ethyl-O-gamma-folyl curcumin (10) have been synthesized and tested for their Antibacterial and Antiviral activities. The conjugates 2, 3, 4, 6 and 8 have shown very promising Antibacterial activity with MIC ranging between 0.09 and 0.67 microM against Gram-positive cocci and Gram-negative bacilli. Further, the conjugates 2, 3, 6, 8 and 10 have been screened for their Antiviral activities against HSV, VSV, FIPV, PIV-3, RSV and FHV and the molecules 2 and 3 have shown good results with EC(50) 0.011 microM and 0.029 microM against VSV and FIPV/FHV, respectively. However, the molecules did not show expected results against HIV-1 III(B) and ROD strains in MTT assay.

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