2. Academic Validation
  3. 6-Substituted 2-(N-trifluoroacetylamino)imidazopyridines induce cell cycle arrest and apoptosis in SK-LU-1 human cancer cell line

6-Substituted 2-(N-trifluoroacetylamino)imidazopyridines induce cell cycle arrest and apoptosis in SK-LU-1 human cancer cell line

  • Eur J Med Chem. 2010 Mar;45(3):1211-9. doi: 10.1016/j.ejmech.2009.11.049.
Miguel Angel Martínez-Urbina 1,  Alejandro Zentella,  Miguel Angel Vilchis-Reyes,  Angel Guzmán,  Omar Vargas,  María Teresa Ramírez Apan,  José Luis Ventura Gallegos,  Eduardo Díaz
Affiliations

Affiliation

  • 1 Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, México 04510, DF, México.
PMID: 20045224 DOI: 10.1016/j.ejmech.2009.11.049
Abstract

A series of 6-substituted 2-(N-trifluoroacetylamino)imidazopyridines have been synthesized and their bioactivities were evaluated. Compounds 6a, 6c, and 11a were the most active compounds with modest cytotoxic activity against six human Cancer cell lines U251 (glioma), PC-3 (prostate), K-562 (leukemia), HCT-15 (colon), MCF7 (breast) and SK-LU-1 (lung). The cell cycle analysis showed that compounds 6a, 6c, and 11a induce a G2/M phase cell cycle arrest on SK-LU-1 cell line where inhibition of CDK-1 and CDK-2 may be implicated.

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