2. Academic Validation
  3. Evaluation of 3,4-dihydroquinazoline-2(1H)-thiones as inhibitors of alpha-MSH-induced melanin production in melanoma B16 cells

Evaluation of 3,4-dihydroquinazoline-2(1H)-thiones as inhibitors of alpha-MSH-induced melanin production in melanoma B16 cells

  • Bioorg Med Chem. 2010 Feb 15;18(4):1555-62. doi: 10.1016/j.bmc.2010.01.005.
P Thanigaimalai 1,  Ki-Cheul Lee,  Seong-Cheol Bang,  Jee-Hyun Lee,  Cheong-Yong Yun,  Eunmiri Roh,  Bang-Yeon Hwang,  Youngsoo Kim,  Sang-Hun Jung
Affiliations

Affiliation

  • 1 College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305-764, Republic of Korea.
PMID: 20097083 DOI: 10.1016/j.bmc.2010.01.005
Abstract

Novel 3,4-dihydroquinazoline-2(1H)-thiones (QNTs) 1 were found to be potent inhibitors of alpha-MSH-induced melanin production. The effect of QNTs to inhibit melanin formation in B16 melanoma cells was screened in the presence of alpha-MSH. In defining the mechanism of activity, the effects on Tyrosinase activity, on Tyrosinase synthesis and on the depigmentation of melanin were evaluated. QNTs did not affect the catalytic activity of Tyrosinase, but rather acted as an inhibitor of Tyrosinase synthesis.

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