1. Academic Validation
  2. Chemical constituents from the leaves and stems of Schisandra rubriflora

Chemical constituents from the leaves and stems of Schisandra rubriflora

  • J Nat Prod. 2010 Feb 26;73(2):221-5. doi: 10.1021/np900849y.
Wei-Lie Xiao 1 Shi-Ying Yang Liu-Meng Yang Guang-Yu Yang Rui-Rui Wang Hai-Bo Zhang Wei Zhao Jian-Xin Pu Yang Lu Yong-Tang Zheng Han-Dong Sun
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
Abstract

Six new nortriterpenoids, schirubridilactones A-F (1-6), as well as 14 known compounds, were isolated from the leaves and stems of Schisandra rubriflora. The structures of 1-6 were elucidated on the basis of spectroscopic methods including HSQC, HMBC, (1)H-(1)H COSY, and ROESY NMR experiments. The relative stereochemistry of 1 was confirmed through single-crystal X-ray analysis. In addition, compounds 1-6 showed anti-HIV-1 activity with EC(50) values in the range 14.3-80.8 microg/mL and selectivity indices in the range 2.2-9.0.

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