2. Academic Validation
  3. Cytotoxicity against KB and NCI-H187 cell lines of modified flavonoids from Kaempferia parviflora

Cytotoxicity against KB and NCI-H187 cell lines of modified flavonoids from Kaempferia parviflora

  • Bioorg Med Chem Lett. 2010 May 1;20(9):2821-3. doi: 10.1016/j.bmcl.2010.03.054.
Chavi Yenjai 1,  Suchana Wanich
Affiliations

Affiliation

  • 1 Natural Products Research Unit, Center for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand. chayen@kku.ac.th
PMID: 20362442 DOI: 10.1016/j.bmcl.2010.03.054
Abstract

Flavones 1-4 isolated from Kaempferia parviflora were used for structural modification. Sixteen flavonoid derivatives, including four new derivatives, were synthesized and evaluated for cytotoxicity against KB and NCI-H187 cell lines. Flavanones 2a-4a demonstrated higher cytotoxic activity than the parent compounds. Cytotoxicity against KB cell line of oxime 1c was about 7 times higher than the ellipticine standard. Interestingly, oximes 1c and 2c exhibited highly potent cytotoxicity against NCI-H187 cell line with IC(50) values of 0.014 and 0.23 microM, respectively. Oximes 4c and 5c showed strong cytotoxicity against NCI-H187 cell line with IC(50) values of 4.04 and 2.32 microM, respectively.

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