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  3. On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X(7) receptor antagonist A-438079

On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X(7) receptor antagonist A-438079

  • J Neural Transm (Vienna). 2010 Jun;117(6):681-7. doi: 10.1007/s00702-010-0400-0.
Daniel Marcellino 1,  Diana Suárez-Boomgaard,  María Dolores Sánchez-Reina,  José A Aguirre,  Takashi Yoshitake,  Shimako Yoshitake,  Beth Hagman,  Jan Kehr,  Luigi F Agnati,  Kjell Fuxe,  Alicia Rivera
Affiliations

Affiliation

  • 1 Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden. Daniel.Marcellino@ki.se
PMID: 20387084 DOI: 10.1007/s00702-010-0400-0
Abstract

The role of the ATP-gated receptor, P2X(7), has been evaluated in the unilateral 6-OHDA rat model of Parkinson's disease using the P2X(7) competitive antagonist A-438079. Nigral P2X(7) immunoreactivity was mainly located in microglia but also in astroglia. A-438079 partially but significantly prevented the 6-OHDA-induced depletion of striatal DA stores. However, this was not associated with a reduction of DA cell loss. Blockade of P2X(7) receptors may represent a novel protective strategy for striatal DA terminals in Parkinson's disease and warrants further future investigation.

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