2. Academic Validation
  3. Synthesis and evaluation of beta-carboline derivatives as inhibitors of human immunodeficiency virus

Synthesis and evaluation of beta-carboline derivatives as inhibitors of human immunodeficiency virus

  • Bioorg Med Chem Lett. 2010 Aug 1;20(15):4416-9. doi: 10.1016/j.bmcl.2010.06.052.
Keyur G Brahmbhatt 1,  Nafees Ahmed,  Sudeep Sabde,  Debashis Mitra,  Inder Pal Singh,  Kamlesh K Bhutani
Affiliations

Affiliation

  • 1 Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Punjab, India.
PMID: 20598537 DOI: 10.1016/j.bmcl.2010.06.052
Abstract

A series of beta-carboline derivatives were synthesized by utilizing aromatization and chemoselective alkylation method recently reported from our laboratory. Synthesized derivatives were evaluated for anti-HIV activity in human CD4+ T cell line (CEM-GFP) infected with HIV-1 NL(4.3) virus. 1-Formyl-beta-carboline-3-carbxylic acid methyl ester (15) showed inhibition of human immunodeficiency virus at IC(50)=2.9 microM.

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