2. Academic Validation
  3. Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones

Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones

  • Eur J Med Chem. 2010 Nov;45(11):5474-9. doi: 10.1016/j.ejmech.2010.07.058.
Krishnan Suresh Kumar 1,  Swastika Ganguly,  Ravichandran Veerasamy,  Erik De Clercq
Affiliations

Affiliation

  • 1 Medicinal chemistry research Laboratory, KMCH College of Pharmacy, Coimbatore, India. pharmsuki@gmail.com
PMID: 20724039 DOI: 10.1016/j.ejmech.2010.07.058
Abstract

A new series of 3-(benzylideneamino)-2-phenylquinazoline-4(3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4(3)H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and Antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), vaccinia virus, vesicular stomatitis virus, herpes simplex virus-1 TK- KOS ACVr, para influenza-3 virus, reovirus-1, Sindbis virus, Coxsackie virus B4, Punta Toro virus, feline corona virus (FIPV), feline herpes virus, respiratory syncytial virus, influenza A H1N1 subtype, influenza A H3N2 subtype, and influenza B virus. Compound 2a showed better Antiviral activity against the entire tested virus.

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