2. Academic Validation
  3. Cytotoxic triterpenoids from Maytenus retusa

Cytotoxic triterpenoids from Maytenus retusa

  • J Nat Prod. 2010 Dec 27;73(12):2029-34. doi: 10.1021/np100517u.
Sandra M Oramas-Royo 1,  Haydee Chávez,  Patricia Martín-Rodíguez,  Leandro Fernández-Pérez,  Angel G Ravelo,  Ana Estévez-Braun
Affiliations

Affiliation

  • 1 Instituto Universitario de Bio-Orgánica Antonio González, Avenida Astrofísico Francisco Sánchez 2, La Laguna, Tenerife, Spain.
PMID: 21090801 DOI: 10.1021/np100517u
Abstract

Seven new triterpenoids (1-7) and 36 known compounds were isolated from the root bark of Maytenus retusa. Their structures were determined by 1D and 2D spectroscopic studies. Several compounds were evaluated for their cytotoxicity against the human tumor cell lines HL-60 and MCF-7. Some of them were cytotoxic, with IC(50) values ranging between 0.2 and 4.7 μM.

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