2. Academic Validation
  3. ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1)

ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1)

  • Nat Immunol. 2011 Feb;12(2):178-85. doi: 10.1038/ni.1983.
Zhenhu Li 1,  Yuan Zhang,  Zhiduo Liu,  Xiaodong Wu,  Yuhan Zheng,  Zhiyun Tao,  Kairui Mao,  Jie Wang,  Guomei Lin,  Lin Tian,  Yongyong Ji,  Meiling Qin,  Shuhui Sun,  Xueliang Zhu,  Bing Sun
Affiliations

Affiliation

  • 1 Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
PMID: 21217760 DOI: 10.1038/ni.1983
Abstract

Type 2 helper T cells (T(H)2) are critically involved in allergies and asthma. Here we demonstrate that extracellular matrix protein-1 (ECM1) is highly and selectively expressed in T(H)2 cells. ECM1 deficiency caused impaired T(H)2 responses and reduced allergic airway inflammation in vivo. Functional analysis demonstrated that although the T(H)2 polarization of ECM1-deficient cells was unimpaired, these cells had a defect in migration and were retained in peripheral lymphoid organs. This was associated with reduced expression of KLF2 and S1P(1). We also found that ECM1 could directly bind the interleukin-2 (IL-2) receptor to inhibit IL-2 signaling and activate S1P(1) expression. Our data identify a previously unknown function of ECM1 in regulating T(H)2 cell migration through control of KLF2 and S1P(1) expression.

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