1. Academic Validation
  2. Bioactive compounds from the fern Lepisorus contortus

Bioactive compounds from the fern Lepisorus contortus

  • J Nat Prod. 2011 Feb 25;74(2):129-36. doi: 10.1021/np100373f.
Jian-Hong Yang 1 Tamara P Kondratyuk Katherine C Jermihov Laura E Marler Xi Qiu Yongsoo Choi Hongmei Cao Rui Yu Megan Sturdy Rong Huang Ying Liu Li-Qin Wang Andrew D Mesecar Richard B van Breemen John M Pezzuto Harry H S Fong Ye-Gao Chen Hong-Jie Zhang
Affiliations

Affiliation

  • 1 Department of Chemistry, Yunnan Normal University, Kunming 650092, People's Republic of China.
Abstract

Phytochemical investigation of the whole plant of Lepisorus contortus (Christ) Ching led to the isolation of five new phenylethanoid glycosides (1-5), each containing a caffeoyl group, a new flavonoid glycoside (10), and 14 known compounds (6-9 and 11-15, syringic acid, vanillic acid, phloretic acid, diplopterol, and β-sitosterol). This is the first report of phenylethanoid glycosides from the family Polypodiaceae. Compounds 1-15 were evaluated for their Cancer chemopreventive potential based on their ability to inhibit tumor necrosis factor alpha (TNF-α)-induced NF-κB activity, nitric oxide (NO) production, and aromatase, quinone reductase 2 (QR-2), and COX-1/-2 activities. Quercetin-3-O-β-d-glucoside (15) demonstrated inhibition against QR2 with an IC(50) value of 3.84 μM, which confirmed kaempferol/quercetin glycosides as the active compounds to inhibit QR2. The compound also demonstrated NF-κB activity with an IC(50) value of 33.6 μM. In addition, compounds 1, 2, 4, and 6 showed aromatase activity with IC(50) values of 30.7, 32.3, 26.8, and 35.3 μM, respectively.

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