2. Academic Validation
  3. Lack of binding of gestodene to estrogen receptor in human breast cancer tissue

Lack of binding of gestodene to estrogen receptor in human breast cancer tissue

  • Eur J Cancer. 1990;26(5):608-10. doi: 10.1016/0277-5379(90)90089-c.
K Pollow 1,  M Juchem,  H J Grill,  W Elger,  S Beier,  K Schmidt-Gollwitzer,  B Manz
Affiliations

Affiliation

  • 1 Department of Experimental Endocrinology, Johannes Gutenberg-Universität Mainz, F.R.G.
PMID: 2144750 DOI: 10.1016/0277-5379(90)90089-c
Abstract

Competition studies with progesterone and estradiol receptors of human myometrial tissue as well as of mammary Cancer tissue showed that gestodene bound with high affinity to the Progesterone Receptor, as did Other synthetic and natural progestogens. However, gestodene did not bind to the estradiol receptor. The relative binding affinities of all tested synthetic and natural ligands showed no organ-specific differences and no differences between neoplastically transformed and normal tissues.

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