2. Academic Validation
  3. Fusarisetin A, an acinar morphogenesis inhibitor from a soil fungus, Fusarium sp. FN080326

Fusarisetin A, an acinar morphogenesis inhibitor from a soil fungus, Fusarium sp. FN080326

  • J Am Chem Soc. 2011 May 11;133(18):6865-7. doi: 10.1021/ja1110688.
Jae-Hyuk Jang 1,  Yukihiro Asami,  Jun-Pil Jang,  Sun-Ok Kim,  Dong Oh Moon,  Kee-Sun Shin,  Daisuke Hashizume,  Makoto Muroi,  Tamio Saito,  Hyuncheol Oh,  Bo Yeon Kim,  Hiroyuki Osada,  Jong Seog Ahn
Affiliations

Affiliation

  • 1 Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gun, Chungbuk 363-883, Republic of Korea.
PMID: 21500849 DOI: 10.1021/ja1110688
Abstract

An acinar morphogenesis inhibitor named fusarisetin A (1) that possesses both an unprecedented carbon skeleton and a new pentacyclic ring system has been identified from an in-house fractionated Fungal library using a three-dimensional matrigel-induced acinar morphogenesis assay system. The structure of 1 was determined in detail by NMR and circular dichroism spectroscopy, X-ray analysis, and chemical reaction experiments.

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