2. Academic Validation
  3. Synthesis and in vitro anti-HIV activity of N-1,3-benzo[d]thiazol-2-yl-2-(2-oxo-2H-chromen-4-yl)acetamide derivatives using MTT method

Synthesis and in vitro anti-HIV activity of N-1,3-benzo[d]thiazol-2-yl-2-(2-oxo-2H-chromen-4-yl)acetamide derivatives using MTT method

  • Bioorg Med Chem Lett. 2011 Jun 1;21(11):3443-6. doi: 10.1016/j.bmcl.2011.03.105.
Dhairya Bhavsar 1,  Jalpa Trivedi,  Shrey Parekh,  Mahesh Savant,  Shailesh Thakrar,  Abhay Bavishi,  Ashish Radadiya,  Hardevsinh Vala,  Jignesh Lunagariya,  Manisha Parmar,  Ladwa Paresh,  Roberta Loddo,  Anamik Shah
Affiliations

Affiliation

  • 1 Department of Chemistry, Saurashtra University, Rajkot 360005, India.
PMID: 21515046 DOI: 10.1016/j.bmcl.2011.03.105
Abstract

A series of novel N-1,3-benzo[d]thiazol-2-yl-2-(2-oxo-2H-chromen-4-yl)acetamide derivatives has been synthesized. All the newly synthesized compounds were evaluated for their anti-HIV activity using MTT method. Most of these compounds showed moderate to potent activity against wild-type HIV-1 with an EC(50) ranging from >7 EC(50) [μg/ml] to <100 EC(50) [μg/ml]. Among them, N-1,3-benzo[d]thiazol-2-yl-2-(2-oxo-2H-chromen-4-yl)acetamide 6v was identified as the most promising compound (EC(50)=<7 μg/ml). Among all the compounds, three compounds 6m, 6v and 6u have been exhibits potent anti-HIV activity against MT-4 cells.

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