2. Academic Validation
  3. Structure and cytotoxicity of diterpenoids from Isodon adenolomus

Structure and cytotoxicity of diterpenoids from Isodon adenolomus

  • J Nat Prod. 2011 May 27;74(5):1213-20. doi: 10.1021/np200140j.
Wei Zhao 1,  Jian-Xin Pu,  Xue Du,  Jia Su,  Xiao-Nian Li,  Jian-Hong Yang,  Yong-Bo Xue,  Yan Li,  Wei-Lie Xiao,  Han-Dong Sun
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
PMID: 21534539 DOI: 10.1021/np200140j
Abstract

Twelve new Diterpenoids, isoadenolins A-L (1-12), and 24 known ones were isolated from the aerial parts of Isodon adenolomus. Their structures were identified using spectroscopic data, and the absolute configurations of 1 and 14 were determined by single-crystal X-ray diffraction. Selected compounds were evaluated for their in vitro cytotoxicity against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. Compounds 9, 13-16, and 21 showed significant inhibitory effects on all five cells, with IC50 values in the range 0.7-9.7 μM.

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