2. Academic Validation
  3. Tigliane-type diterpenoid glycosides from Euphorbia fischeriana

Tigliane-type diterpenoid glycosides from Euphorbia fischeriana

  • J Nat Prod. 2011 Jun 24;74(6):1508-12. doi: 10.1021/np200058c.
Li-Li Pan 1,  Ping-Lei Fang,  Xing-Jie Zhang,  Wei Ni,  Lei Li,  Liu-Meng Yang,  Chang-Xiang Chen,  Yong-Tang Zheng,  Chang-Tian Li,  Xiao-Jiang Hao,  Hai-Yang Liu
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany , Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
PMID: 21534540 DOI: 10.1021/np200058c
Abstract

Investigation of whole Plants of Euphorbia fischeriana afforded three new tigliane-diterpenoid glycosides, fischerosides A-C (1-3), together with 11 known Diterpenoids. Fischerosides A-C (1-3) are the first tigliane-type diterpenoid glucosides. Their structures were determined by a combination of 1D and 2D NMR, MS, and acid hydrolysis. Inhibitory activity against HIV-1 was assessed for compounds 1-5. The new compound 3 showed an EC₅₀ value of 0.02 μM and a therapeutic index (TI) of 17.50, while prostratin (4) and 12-deoxyphorbol-13,20-diacetate (5) showed significantly greater anti-HIV-1 activity.

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