2. Academic Validation
  3. Vasoactive intestinal contractor, a novel peptide, shares a common receptor with endothelin-1 and stimulates Ca2+ mobilization and DNA synthesis in Swiss 3T3 cells

Vasoactive intestinal contractor, a novel peptide, shares a common receptor with endothelin-1 and stimulates Ca2+ mobilization and DNA synthesis in Swiss 3T3 cells

  • Biochem Biophys Res Commun. 1990 Feb 28;167(1):161-7. doi: 10.1016/0006-291x(90)91745-e.
I Fabregat 1,  E Rozengurt
Affiliations

Affiliation

  • 1 Imperial Cancer Research Fund, London, U.K.
PMID: 2155611 DOI: 10.1016/0006-291x(90)91745-e
Abstract

Vasoactive intestinal contractor peptide (VIC), a novel member of the endothelin family, stimulated a rapid increase in the intracellular Ca2+ concentration in fura-2-loaded Swiss 3T3 cells. Sequential addition of VIC and endothelin-1 (ET1) demonstrated the induction of both homologous and heterologous desensitization. VIC was as potent as ET1 in displacing the binding of 125I-ET1 and in stimulating mitogenesis in Swiss 3T3 cells. These findings suggest that VIC and ET1 share a common receptor in Swiss 3T3 cells.

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