2. Academic Validation
  3. Indole alkaloids and quassinoids from the stems of Brucea mollis

Indole alkaloids and quassinoids from the stems of Brucea mollis

  • J Nat Prod. 2011 Nov 28;74(11):2438-45. doi: 10.1021/np200712y.
Hui Chen 1,  Jian Bai,  Zhen-Feng Fang,  Shi-Shan Yu,  Shuang-Gang Ma,  Song Xu,  Yong Li,  Jing Qu,  Jin-Hong Ren,  Li Li,  Yi-Kang Si,  Xiao-Guang Chen
Affiliations

Affiliation

  • 1 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
PMID: 22070654 DOI: 10.1021/np200712y
Abstract

Seven new Indole Alkaloids, bruceollines H-N (1-7), three new quassinoids, yadanziolides T-V (10-12), and four known analogues, bruceolline E (8), bruceolline F (9), bruceine D (13), and yadanziolide B (14), were isolated from an ethanol extract of the stems of Brucea mollis. The absolute configurations of compounds 2 and 5 were determined by comparison of their experimental and calculated ECD spectra. The absolute configuration of the known compound 9 was determined by using Mo2(OAc)4-induced CD analysis for the first time. Compounds 10, 13, and 14 exhibited cytotoxic activities with IC50 values of 3.00-5.81 μM.

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