Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus

Bioorg Med Chem Lett. 2012 Jan 1;22(1):225-30. doi: 10.1016/j.bmcl.2011.11.059.

Thaís Moreira Osório ¹, Franco Delle Monache, Louise Domeneghini Chiaradia, Alessandra Mascarello, Taisa Regina Stumpf, Carlos Roberto Zanetti, Douglas Bardini Silveira, Célia Regina Monte Barardi, Elza de Fatima Albino Smânia, Aline Viancelli, Lucas Ariel Totaro Garcia, Rosendo Augusto Yunes, Ricardo José Nunes, Artur Smânia Jr

Affiliations

Affiliation

1 Laboratório de Antibióticos, Universidade Federal de Santa Catarina (UFSC), Campus Trindade, CEP: 88040-900 Florianópolis, SC, Brazil. thisosorio@bol.com.br

PMID: 22169259 DOI: 10.1016/j.bmcl.2011.11.059

Abstract

The increase in Antibiotic resistance due to multiple factors has encouraged the search for new compounds which are active against multidrug-resistant pathogens. In this context, Chalcones, Dihydrochalcones, hydrazones and oxadiazoles were tested against Staphylococcus aureus ATCC 25923 and methicillin-resistant S. aureus (MRSA) isolates, which were obtained from clinical laboratories and were characterized as MRSA using traditional and molecular methods. Among 65 tested compounds, two Chalcones, one dihydrochalcone and two hydrazones were active against MRSA. Based on the minimal inhibitory concentration and cytotoxicity, hydrazones provided a better selectivity index than Chalcones. Active hydrazones are promising antibiotic-like substances and they should be the subject of further microbiological studies.

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