2. Academic Validation
  3. Conjugation of cell-penetrating peptides leads to identification of anti-HIV peptides from matrix proteins

Conjugation of cell-penetrating peptides leads to identification of anti-HIV peptides from matrix proteins

  • Bioorg Med Chem. 2012 Feb 15;20(4):1468-74. doi: 10.1016/j.bmc.2011.12.055.
Tetsuo Narumi 1,  Mao Komoriya,  Chie Hashimoto,  Honggui Wu,  Wataru Nomura,  Shintaro Suzuki,  Tomohiro Tanaka,  Joe Chiba,  Naoki Yamamoto,  Tsutomu Murakami,  Hirokazu Tamamura
Affiliations

Affiliation

  • 1 Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo 101-0062, Japan.
PMID: 22277590 DOI: 10.1016/j.bmc.2011.12.055
Abstract

Compounds which inhibit the HIV-1 replication cycle have been found amongst fragment Peptides derived from an HIV-1 matrix (MA) protein. Overlapping peptide libraries covering the whole sequence of MA were designed and constructed with the addition of an octa-arginyl group to increase their cell membrane permeability. Imaging experiments with fluorescent-labeled Peptides demonstrated these Peptides with an octa-arginyl group can penetrate cell membranes. The fusion of an octa-arginyl group was proven to be an efficient way to find active Peptides in cells such as HIV-inhibitory Peptides.

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