2. Academic Validation
  3. Chlorinated englerins with selective inhibition of renal cancer cell growth

Chlorinated englerins with selective inhibition of renal cancer cell growth

  • J Nat Prod. 2012 Mar 23;75(3):459-63. doi: 10.1021/np200905u.
Rhone K Akee 1,  Tanya Ransom,  Ranjala Ratnayake,  James B McMahon,  John A Beutler
Affiliations

Affiliation

  • 1 Natural Products Support Group, SAIC-Frederick National Cancer Institute, Frederick, Maryland 21702, United States.
PMID: 22280462 DOI: 10.1021/np200905u
Abstract

The chlorinated englerins (3-9) were isolated from Phyllanthus engleri and shown to selectively inhibit the growth of renal Cancer cells. The compounds were shown to be extraction artifacts produced by exposure to chloroform decomposition products during their isolation. The most active compound, 3, was synthesized from englerin A (1).

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