2. Academic Validation
  3. Hybrids of privileged structures benzothiazoles and pyrrolo[2,1-c] [1,4]benzodiazepin-5-one, and diversity-oriented synthesis of benzothiazoles

Hybrids of privileged structures benzothiazoles and pyrrolo[2,1-c] [1,4]benzodiazepin-5-one, and diversity-oriented synthesis of benzothiazoles

  • Eur J Med Chem. 2012 Apr:50:27-38. doi: 10.1016/j.ejmech.2012.01.014.
D Subhas Bose 1,  Mohd Idrees,  Ismail K Todewale,  N M Jakka,  J Venkateswara Rao
Affiliations

Affiliation

  • 1 Organic & Biomolecular Chemistry Division, Fine Chemicals Laboratory, Indian Institute of Chemical Technology, Hyderabad 500 007, India. dsb@iict.res.in
PMID: 22325897 DOI: 10.1016/j.ejmech.2012.01.014
Abstract

Privileged structures like Benzothiazole and Pyrrolobenzodiazepine offer wonderful opportunity to explore in anti-cancer drug discovery as a mean to counter drug-resistance problem. BT-PBD hybrids and diverse BT derivatives have been synthesized and their in vitro cytotoxic activities were screened against five Cancer cell lines have been discussed. The novel compounds showed promising results as compared with the marketed drug etoposide and could well be used in future anti-cancer drug development studies.

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