2. Academic Validation
  3. Structure-based design of novel potent protein kinase CK2 (CK2) inhibitors with phenyl-azole scaffolds

Structure-based design of novel potent protein kinase CK2 (CK2) inhibitors with phenyl-azole scaffolds

  • J Med Chem. 2012 Mar 22;55(6):2899-903. doi: 10.1021/jm2015167.
Zengye Hou 1,  Isao Nakanishi,  Takayoshi Kinoshita,  Yoshinori Takei,  Misato Yasue,  Ryosuke Misu,  Yamato Suzuki,  Shinya Nakamura,  Tatsuhide Kure,  Hiroaki Ohno,  Katsumi Murata,  Kazuo Kitaura,  Akira Hirasawa,  Gozoh Tsujimoto,  Shinya Oishi,  Nobutaka Fujii
Affiliations

Affiliation

  • 1 Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
PMID: 22339433 DOI: 10.1021/jm2015167
Abstract

Protein kinase CK2 (CK2) is a ubiquitous serine/threonine protein kinase for hundreds of endogenous substrates. CK2 has been considered to be involved in many diseases, including cancers. Herein we report the discovery of a novel ATP-competitive CK2 Inhibitor. Virtual screening of a compound library led to the identification of a hit 2-phenyl-1,3,4-thiadiazole compound. Subsequent structural optimization resulted in the identification of a promising 4-(thiazol-5-yl)benzoic acid derivative.

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