2. Academic Validation
  3. Galactolipids from Bauhinia racemosa as a new class of antifilarial agents against human lymphatic filarial parasite, Brugia malayi

Galactolipids from Bauhinia racemosa as a new class of antifilarial agents against human lymphatic filarial parasite, Brugia malayi

  • Eur J Med Chem. 2012 Apr:50:230-5. doi: 10.1016/j.ejmech.2012.01.057.
Koneni V Sashidhara 1,  Suriya P Singh,  Sweta Misra,  Jyoti Gupta,  Shailja Misra-Bhattacharya
Affiliations

Affiliation

  • 1 Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226 001, India. sashidhar123@gmail.com
PMID: 22348826 DOI: 10.1016/j.ejmech.2012.01.057
Abstract

Bioassay guided fractionation of ethanolic extract of the leaves of Bauhinia racemosa led to the isolation of galactolipid and catechin class of the compounds (1-7) from the most active n-butanol fraction (F4). Among the active galactolipids, 1 emerged as the lead molecule which was active on both forms of lymphatic filarial Parasite, Brugia malayi. It was found to be better than the standard drug ivermectin and diethylcarbamazine (DEC) in terms of dose and efficacy.

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