Impact of amyloid-β peptide (1-42) on voltage-gated ion currents in molluscan neurons

Bull Exp Biol Med. 2011 Oct;151(6):671-4. doi: 10.1007/s10517-011-1412-y.

E I Solntseva ¹, J V Bukanova, E V Marchenko, V G Skrebitsky

Affiliations

Affiliation

1 Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia. soln@front.ru

PMID: 22485204 DOI: 10.1007/s10517-011-1412-y

Abstract

Different types of voltage-gated ion currents were recorded in isolated neurons of snail Helix pomatia using the two-microelectrode voltage-clamp technique. Application of Amyloid-β peptide (1-42, 1-10 μM) in the bathing solution did not change delayed rectifier K(+)-current and leakage current, but enhanced inactivation of CA(2+)-current and blocked CA(2+)-dependent K(+)-current.

Products

Cat. No.

Product Name

Description

Target

Research Area
HY-P1363

β-Amyloid (1-42), human TFA

99.66%, 42-Amino Acid Peptide

Amyloid-β

Neurological Disease
HY-P1363A

β-Amyloid (1-42), human

99.66%, 42-Amino Acid Peptide

Amyloid-β

Neurological Disease
HY-P1363S

β-Amyloid-¹⁵N (1-42), human TFA

Isotope-Labeled Compounds

Amyloid-β

Neurological Disease
HY-P1363F1

Biotin-β-Amyloid (1-42), human TFA

Biotin Labeled Amyloid-β

Amyloid-β

Neurological Disease

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