1. Academic Validation
  2. Antibacterial anthraquinone derivatives from a sea anemone-derived fungus Nigrospora sp

Antibacterial anthraquinone derivatives from a sea anemone-derived fungus Nigrospora sp

  • J Nat Prod. 2012 May 25;75(5):935-41. doi: 10.1021/np300103w.
Kai-Lin Yang 1 Mei-Yan Wei Chang-Lun Shao Xiu-Mei Fu Zhi-Yong Guo Ru-Fang Xu Cai-Juan Zheng Zhi-Gang She Yong-Cheng Lin Chang-Yun Wang
Affiliations

Affiliation

  • 1 Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
Abstract

Chemical investigation of a marine-derived fungus Nigrospora sp., isolated from an unidentified sea anemone, yielded two new hydroanthraquinone analogues, 4a-epi-9α-methoxydihydrodeoxybostrycin (1) and 10-deoxybostrycin (2), together with seven known anthraquinone derivatives (3-9). The structures of the two new compounds were established through extensive NMR spectroscopy as well as a single-crystal X-ray diffraction analysis using Cu Kα radiation. The Antibacterial activities of compounds 1-9 and 10 acetyl derivatives (6a, 7a, 8a-8g, 9a) were evaluated in vitro. Compound 6a, the acetylated derivative of 6, exhibited promising activity against Bacillus cereus with an MIC value of 48.8 nM, which was stronger than that of the positive control ciprofloxacin (MIC = 1250 nM). Analysis of the Antibacterial screening data for the metabolites and their acetyl derivatives revealed the key structural features required for this activity.

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