Synthesis and cytotoxic activity of new acridine-thiazolidine derivatives

Bioorg Med Chem. 2012 Jun 1;20(11):3533-9. doi: 10.1016/j.bmc.2012.04.007.

Francisco W A Barros ¹, Teresinha Gonçalves Silva, Marina Galdino da Rocha Pitta, Daniel P Bezerra, Letícia V Costa-Lotufo, Manoel Odorico de Moraes, Cláudia Pessoa, Maria Aline F B de Moura, Fabiane C de Abreu, Maria do Carmo Alves de Lima, Suely Lins Galdino, Ivan da Rocha Pitta, Marilia O F Goulart

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Affiliation

1 Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.

PMID: 22546208 DOI: 10.1016/j.bmc.2012.04.007

Abstract

Although their exact role in controlling tumour growth and Apoptosis in humans remains undefined, acridine and thiazolidine compounds have been shown to act as tumour suppressors in most cancers. Based on this finding, a series of novel hybrid 5-acridin-9-ylmethylene-3-benzyl-thiazolidine-2,4-diones were synthesised via N-alkylation and Michael reaction. The cell viability was analysed using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and DNA interaction assays were performed using electrochemical techniques.

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