2. Academic Validation
  3. Truncated phosphonated C-1'-branched N,O-nucleosides: a new class of antiviral agents

Truncated phosphonated C-1'-branched N,O-nucleosides: a new class of antiviral agents

  • Bioorg Med Chem. 2012 Jun 1;20(11):3652-7. doi: 10.1016/j.bmc.2012.03.047.
Roberto Romeo 1,  Caterina Carnovale,  Salvatore V Giofrè,  Giovanni Romeo,  Beatrice Macchi,  Caterina Frezza,  Francesca Marino-Merlo,  Venerando Pistarà,  Ugo Chiacchio
Affiliations

Affiliation

  • 1 Dipartimento Farmaco-Chimico, Università of Messina, 98168 Messina, Italy. robromeo@unime.it
PMID: 22549138 DOI: 10.1016/j.bmc.2012.03.047
Abstract

Truncated phosphonated C-1'-branched N,O-nucleosides have been synthesized in good yields by 1,3-dipolar cycloaddition methodology, starting from N-methyl-C-(diethoxyphosphoryl)nitrone 7. Preliminary biological assays show that β-anomers are able to inhibit HIV in vitro Infection at concentrations in the micromolar range. Higher SI values with respect to AZT indicated that the compounds were endowed with low cytotoxicity.

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