2. Academic Validation
  3. D-ring modified novel isosteviol derivatives: design, synthesis and cytotoxic activity evaluation

D-ring modified novel isosteviol derivatives: design, synthesis and cytotoxic activity evaluation

  • Bioorg Med Chem Lett. 2012 Sep 15;22(18):5827-32. doi: 10.1016/j.bmcl.2012.07.083.
Tao Zhang 1,  Li-Hui Lu,  Hao Liu,  Jun-Wei Wang,  Rui-Xue Wang,  Yun-Xiao Zhang,  Jing-Chao Tao
Affiliations

Affiliation

  • 1 College of Chemistry and Molecular Engineering, New Drug Research & Development Center, Zhengzhou University, 75 Daxue Road, Zhengzhou 450052, PR China.
PMID: 22901386 DOI: 10.1016/j.bmcl.2012.07.083
Abstract

A series of polyhydric, amino alcohol and tricyclic derivatives were facilely synthesized by D-ring modification of isosteviol. These compounds were screened for their cytotoxic activities against four human tumor cell lines in vitro. Among them, the 15-α-aminomethyl-16-β-hydroxyl isosteviol 23 exhibits significant cytotoxicity superior to the positive control (cisplatin) against EC9706, PC-3 and HCT-116 cell lines.

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