2. Academic Validation
  3. SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions

SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions

  • J Biol Chem. 2012 Sep 7;287(37):30897-905. doi: 10.1074/jbc.R111.309302.
Ghia Euskirchen 1,  Raymond K Auerbach,  Michael Snyder
Affiliations

Affiliation

  • 1 Department of Genetics, Stanford University School of Medicine, Stanford, California 94305-5120, USA.
PMID: 22952240 DOI: 10.1074/jbc.R111.309302
Abstract

Chromatin-remodeling Enzymes play essential roles in many biological processes, including gene expression, DNA replication and repair, and cell division. Although one such complex, SWI/SNF, has been extensively studied, new discoveries are still being made. Here, we review SWI/SNF biochemistry; highlight recent genomic and proteomic advances; and address the role of SWI/SNF in human diseases, including Cancer and viral infections. These studies have greatly increased our understanding of complex nuclear processes.

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