2. Academic Validation
  3. Guadial A and psiguadials C and D, three unusual meroterpenoids from Psidium guajava

Guadial A and psiguadials C and D, three unusual meroterpenoids from Psidium guajava

  • Org Lett. 2012 Oct 19;14(20):5262-5. doi: 10.1021/ol302423b.
Meng Shao 1,  Ying Wang,  Yu-Qing Jian,  Xiao-Jun Huang,  Dong-Mei Zhang,  Qing-Fa Tang,  Ren-Wang Jiang,  Xue-Gang Sun,  Zhi-Ping Lv,  Xiao-Qi Zhang,  Wen-Cai Ye
Affiliations

Affiliation

  • 1 Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou 510632, PR China.
PMID: 23020279 DOI: 10.1021/ol302423b
Abstract

The first monoterpene-based meroterpenoid (1) and two novel sesquiterpene-based ones (2 and 3) with unprecedented skeletons were isolated from the leaves of Psidium guajava. Their structures with absolute configuration were elucidated by extensive spectroscopic studies. A plausible biosynthetic pathway for all meroterpenoids from the title plant is also proposed. Compounds 2 and 3 showed significant cytotoxicity toward HepG2 and HepG2/ADM cells.

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