2. Academic Validation
  3. Antiviral chromones from the stem of Cassia siamea

Antiviral chromones from the stem of Cassia siamea

  • J Nat Prod. 2012 Nov 26;75(11):1909-14. doi: 10.1021/np300395m.
Qiu-Fen Hu 1,  Bin Zhou,  Xue-Mei Gao,  Li-Ying Yang,  Li-Dan Shu,  Yanqiong Shen,  Gan-Peng Li,  Chun-Tao Che,  Guang-Yu Yang
Affiliations

Affiliation

  • 1 Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities , Kunming 650031, Yunnan, People's Republic of China.
PMID: 23078294 DOI: 10.1021/np300395m
Abstract

Seven new chromones, siamchromones A-G (1-7), and 12 known chromones (8-19) were isolated from the stems of Cassia siamea. Compounds 1-19 were evaluated for their antitobacco mosaic virus (anti-TMV) and anti-HIV-1 activities. Compound 6 showed antitobacco mosaic virus (anti-TMV) activity with an inhibition rate of 35.3% and IC50 value of 31.2 μM, which is higher than that of the positive control, ningnamycin. Compounds 1, 10, 13, and 16 showed anti-TMV activities with inhibition rates above 10%. Compounds 4, 6, 13, and 19 showed anti-HIV-1 activities with therapeutic index values above 50.

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