2. Academic Validation
  3. Synthesis and cytotoxicity evaluation of highly functionalized pyranochromenes and pyranopyrans

Synthesis and cytotoxicity evaluation of highly functionalized pyranochromenes and pyranopyrans

  • Bioorg Med Chem Lett. 2012 Dec 1;22(23):7261-4. doi: 10.1016/j.bmcl.2012.09.018.
Narender Reddy Emmadi 1,  Krishnaiah Atmakur,  Ganesh Kumar Chityal,  Sujitha Pombala,  Jagadeesh Babu Nanubolu
Affiliations

Affiliation

  • 1 Crop Protection Chemicals Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India.
PMID: 23079527 DOI: 10.1016/j.bmcl.2012.09.018
Abstract

A series of fluorinated tetrahydropyrano[3,2-c]chromenes and dihydropyrano[3,2-b]pyran derivatives have been synthesized and their in vitro cytotoxic activities have been determined in cervical Cancer cell line (HeLa), human breast adenocarcinoma cell line (MDA-MB-231 and MCF-7) and human alveolar adenocarcinoma cell line (A549). Compounds 4g, 4k, 4p showed a very potent activity against MDA-MB-231, and 4c, 4p showed promising activity against MCF-7, while compounds 4c, 4g, 4p showed moderate activity against HeLa.

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