2. Academic Validation
  3. Synthesis of fluorescent ristocetin aglycon derivatives with remarkable antibacterial and antiviral activities

Synthesis of fluorescent ristocetin aglycon derivatives with remarkable antibacterial and antiviral activities

  • Eur J Med Chem. 2012 Dec:58:361-7. doi: 10.1016/j.ejmech.2012.10.030.
Attila Sipos 1,  Gábor Máté,  Erzsébet Rőth,  Anikó Borbás,  Gyula Batta,  Ilona Bereczki,  Sándor Kéki,  István Jóna,  Eszter Ostorházi,  Ferenc Rozgonyi,  Evelien Vanderlinden,  Lieve Naesens,  Pál Herczegh
Affiliations

Affiliation

  • 1 Department of Pharmaceutical Chemistry, Medical and Health Science Centre, University of Debrecen, Egyetem tér 1, H-4010 Debrecen, Hungary. sipos.attila@pharm.unideb.hu
PMID: 23149298 DOI: 10.1016/j.ejmech.2012.10.030
Abstract

Isoindole and benzoisoindole derivatives of ristocetin aglycon have been prepared by reaction with o-phthalaldehyde or naphthalene-2,3-dialdehyde and various thiols. The new compounds exhibited potent Antibacterial and anti-influenza virus activity. The cluster forming and fluorescent properties of the aglycon derivatives were also studied.

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