2. Academic Validation
  3. Synthesis, antimalarial activity and cytotoxic potential of new monocarbonyl analogues of curcumin

Synthesis, antimalarial activity and cytotoxic potential of new monocarbonyl analogues of curcumin

  • Bioorg Med Chem Lett. 2013 Jan 1;23(1):112-6. doi: 10.1016/j.bmcl.2012.11.004.
Sunny Manohar 1,  Shabana I Khan,  Shamseer Kulangara Kandi,  Kranthi Raj,  Guojing Sun,  Xiaochuan Yang,  Angie D Calderon Molina,  Nanting Ni,  Binghe Wang,  Diwan S Rawat
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Delhi, Delhi 110007, India.
PMID: 23218718 DOI: 10.1016/j.bmcl.2012.11.004
Abstract

A series of novel monocarbonyl analogues of curcumin have been designed, synthesized and tested for their activity against Molt4, HeLa, PC3, DU145 and KB Cancer cell lines. Six of the analogues showed potent cytotoxicity towards these cell lines with IC(50) values below 1 μM, which is better than doxorubicin, a US FDA approved drug. Several analogues were also found to be active against both CQ-resistant (W2 clone) and CQ-sensitive (D6) strains of Plasmodium falciparum in an in-vitro antimalarial screening. This level of activity warrants further investigation of the compounds for development as Anticancer and antimalarial agents.

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