2. Academic Validation
  3. Phenolic compounds from Caesalpinia sappan heartwood and their anti-inflammatory activity

Phenolic compounds from Caesalpinia sappan heartwood and their anti-inflammatory activity

  • J Nat Prod. 2012 Dec 28;75(12):2069-75. doi: 10.1021/np3003673.
To Dao Cuong 1,  Tran Manh Hung,  Jin Cheol Kim,  Eun Hee Kim,  Mi Hee Woo,  Jae Sue Choi,  Jeong Hyung Lee,  Byung Sun Min
Affiliations

Affiliation

  • 1 College of Pharmacy, Catholic University of Daegu, Gyeongsan, Gyeongbuk 712-702, Korea.
PMID: 23234407 DOI: 10.1021/np3003673
Abstract

Four new phenolic compounds, caesalpiniaphenols A-D (1-4), together with eight known compounds were isolated from Caesalpinia sappan heartwood. The chemical structures were established mainly by NMR, MS, ECD, and Mosher's method. Compounds 4, 5, and 7 showed weak inhibitory activity against the LPS-induced NO production in macrophage RAW264.7 cells with IC(50) values of 12.2, 3.5, and 5.7 μM, respectively.

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