1. Academic Validation
  2. Dibenzocyclooctadiene lignans and norlignans from fruits of Schisandra wilsoniana

Dibenzocyclooctadiene lignans and norlignans from fruits of Schisandra wilsoniana

  • J Nat Prod. 2013 Feb 22;76(2):250-5. doi: 10.1021/np300745q.
Guang-Yu Yang 1 Rui-Rui Wang Huai-Xue Mu Yin-Ke Li Xiao-Nian Li Liu-Meng Yang Yong-Tang Zheng Wei-Lie Xiao Han-Dong Sun
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.
Abstract

Seven new dibenzocyclooctadiene Lignans, marlignans M-S (1-7), four new norlignans, marphenols C-F (8-11), and 21 known compounds (12-32) were isolated from the fruits of Schisandra wilsoniana. The structures of 1-11 were elucidated by spectroscopic methods including 1D- and 2D-NMR techniques and CD experiments. Compounds 1-11 were evaluated for their anti-HIV activities and showed EC(50) values in the range 2.97-6.18 μg/mL and therapeutic index values of 5.33-29.13.

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